Publications by authors named "T del Ser"
Plasma biomarkers are promising tools for the screening and diagnosis of dementia in clinical settings. We analyzed plasma levels of Alzheimer's core biomarkers, neurofilament light chain (NfL) and glial fibrillary acid protein (GFAP), through single-molecule Array in 108 patients with Alzheimer's (AD, cerebrospinal fluid with an amyloid+ tau+ neurodegeneration+ profile), 73 patients with frontotemporal dementia (FTD, 24 with genetic diagnosis), and 54 controls. The best area under the curve (AUC) was used to assess the discriminative power.
View Article and Find Full Text PDFPlasma biomarkers represent promising tools for the screening and diagnosis of patients with neurodegenerative conditions. However, it is crucial to account for the effects of aging on biomarker profiles, especially in the oldest segments of the population. Additionally, biomarkers in this sample can offer in vivo insights into the physiological mechanisms underlying brain aging while concomitantly supporting cognitive preservation.
View Article and Find Full Text PDFArticle Synopsis
- Poststroke cognitive impairment is common, but the exact changes in cognitive function following a first stroke compared to pre-stroke levels are not fully understood.
- The study aimed to track cognitive performance over time in stroke survivors versus individuals without strokes, using data from 14 international cohorts of older adults.
- Results showed that incident stroke led to a significant immediate drop in overall cognitive skills and accelerated decline in cognitive abilities over time.
Article Synopsis
- The study investigates how cardiometabolic multimorbidity (CMM) and depression affect cognitive function in older adults, aiming to understand their individual and combined impacts.
- It harmonizes data from 14 international cohort studies and utilizes various scales to assess CMM and depression among participants who did not have dementia at the start of the study.
- Findings include the analysis of over 30,000 older adults, revealing that both CMM and depression are linked to cognitive decline, with further validation through additional studies across different settings.
Background: The relative importance of different components of cognitive reserve (CR), as well as their differences by gender, are poorly established.
Objective: To explore several dimensions of CR, their differences by gender, and their effects on cognitive performance and trajectory in a cohort of older people without relevant psychiatric, neurologic, or systemic conditions.
Methods: Twenty-one variables related to the education, occupation, social activities, and life habits of 1,093 home-dwelling and cognitively healthy individuals, between 68 and 86 years old, were explored using factorial analyses to delineate several dimensions of CR.