Publications by authors named "T Zombori"
Histological grade is a validated prognostic factor of breast cancer but may show alterations following neoadjuvant chemotherapy (NACT). Its reporting after NACT is recommended by several guidelines, but evidence of its retained prognostic impact is scarce. Patients treated with NACT followed by surgery and having sufficient residual tumour for the determination of grade were analysed for the survival effects of posttreatment grade (yG).
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- Glomus tumors (GTs) are mostly benign neoplasms found in the upper gastrointestinal tract, making malignant cases exceptionally rare, which complicates diagnosis due to similarities with other tumors.
- A 52-year-old male patient experienced fatigue and bleeding, leading to the discovery of a gastric GT after multiple examinations, with histopathology confirming it as a potentially malignant tumor.
- The case highlights the need for detailed histopathological and molecular analysis for correct diagnosis and stresses the importance of surgical intervention and long-term monitoring for recurrence and malignancy risks.
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- Human pulmonary dirofilariasis (HPD) is a rare disease caused by the Dirofilaria immitis parasite, typically spread through mosquito bites, with dogs being the main hosts and most cases reported in Mediterranean countries.
- A study in Hungary documented 5 cases of HPD over 12 years, all involving middle-aged patients with tumor-like lung lesions requiring surgical intervention; histological tests confirmed the presence of remnants of the parasite.
- The study emphasizes the need for clinicians to be aware of HPD in diagnoses of lung lesions, as early detection is crucial for effective treatment and to avoid unnecessary surgeries.
Aims: Tumour grading is an essential part of the pathologic assessment that promotes patient management. The International Association for the Study of Lung Cancer (IASLC) proposed a grading system for non-mucinous lung adenocarcinoma in 2020. We aimed to validate the prognostic impact of this novel grading system on overall survival (OS) and recurrence-free survival (RFS) based on literature data.
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- The stem cell theory is the prevailing explanation for cancer, suggesting that cancer stem cells, which can renew themselves and are found in specialized niches, contribute to tumor recurrence and progression.
- In a study focusing on triple-negative breast cancer, researchers analyzed the expression of several stem cell markers—ALDH1, AnnexinA1, CD44, CD117, CD166, Nanog, and oct-4—looking for correlations with patient prognosis.
- While ALDH1 and CD117 were linked to disease-free survival (DFS), and CD44, CD117, and CD166 to overall survival (OS), the study concluded that most markers did not show a significant prognostic impact, highlighting the importance of ALDH1 and CD44 for further