Publications by authors named "T Zelniker"
Soluble ST2 in Heart Failure: A Clinical Role beyond B-Type Natriuretic Peptide.
J Cardiovasc Dev Dis
November 2023
Soluble (s)ST2 has been proposed as a useful biomarker for heart failure (HF) patient management. Myocardial damage or mechanical stress stimulate sST2 release. ST2 competes with a membrane bound receptor (ST2 ligand, or ST2L) for interleukin-33 (IL-33) binding, inhibiting the effects induced by the ST2L/IL-33 interaction so that excessive sST2 may contribute to myocardial fibrosis and ventricular remodeling.
View Article and Find Full Text PDFTemporal trends and outcomes of patients with chronic limb-threatening ischemia with and without history of coronary artery disease: insights from the us national inpatient sample database.
J Invasive Cardiol
October 2023
Article Synopsis
- - The study examines the rising prevalence of coronary artery disease (CAD) in adults with chronic limb-threatening ischemia (CLTI) from 2000 to 2018, finding that about 23% of CLTI patients also had CAD, which increased over the years from 15.3% to 23.1%.
- - It reports that individuals with CLTI and CAD have a higher risk of in-hospital mortality and complications, such as bleeding requiring transfusion, compared to those without CAD.
- - The research highlights a shift in treatment methods, showing an increase in endovascular procedures over surgical ones for patients with both CAD and CLTI, and suggests a need for improved interventions for this vulnerable group.
Epstein-Barr virus (EBV) reactivation may be involved in long-COVID symptoms, but reactivation of other viruses as a factor has received less attention. Here we evaluated the reactivation of parvovirus-B19 and several members of the Herpesviridae family (DNA viruses) in patients with long-COVID syndrome. We hypothesized that monovalent COVID-19 vaccines inhibit viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, thereby reducing clinical symptoms.
View Article and Find Full Text PDFArticle Synopsis
- Myocardial infarction frequently leads to out-of-hospital cardiac arrests (OHCA), yet the long-term effects of early coronary angiography for patients without ST-segment elevation are unknown.
- The TOMAHAWK trial compared the outcomes of early unselective angiography versus delayed/selective angiography in 554 patients who were successfully resuscitated from OHCA with suspected cardiac causes.
- Results were measured after one year, focusing on all-cause mortality, severe neurological deficits, myocardial infarction rates, and rehospitalization among survivors.