Publications by authors named "T Zelante"
Protective immunity to opportunistic fungal infections consists of tightly regulated innate and adaptive immune responses that clear the infection. Immune responses to infections of the vaginal mucosa by species are, however, an exception. In the case of vulvovaginal candidiasis (VVC), the inflammatory response is associated with symptomatic disease, rather than that it results in pathogen clearance.
View Article and Find Full Text PDFDendritic cells (DCs) are essential orchestrators of immune responses and represent potential targets for immunomodulation in autoimmune diseases. Human amniotic fluid secretome is abundant in immunoregulatory factors, with extracellular vesicles (EVs) being a significant component. However, the impact of these EVs on dendritic cells subsets remain unexplored.
View Article and Find Full Text PDFArticle Synopsis
- CN-NFAT inhibitors are commonly used drugs to suppress T cell responses but can negatively impact innate immune cells, leading to increased susceptibility to infections.
- This study examined how these inhibitors affect human neutrophils' response to fungi like Candida albicans and Aspergillus fumigatus, revealing significant changes in gene expression related to immune response.
- The presence of CN-NFAT inhibitors reduced the production of key chemokines, impairing neutrophils' ability to attract other immune cells, highlighting the inhibitors' broader effects on immune function.
Article Synopsis
- Multiple sclerosis is a serious disease where the immune system attacks the central nervous system, causing inflammation.
- Scientists found that a substance made by gut bacteria, called indole-3-carboxaldehyde (3-IAld), seems to help with this disease by affecting how the body uses a chemical called tryptophan.
- This process could protect the body and might even lead to new treatments for autoimmune diseases like multiple sclerosis.
Article Synopsis
- - Cystic fibrosis (CF) is a genetic disorder that leads to severe lung issues due to defective CFTR function, inflammation, and infections, making it a major health concern even with new treatments.
- - Researchers are exploring sphingosine-1-phosphate (S1P) lyase (SPL) to target inflammation and fungal infections in CF patients by modifying S1P metabolism, showing promising results in mouse models.
- - They have also conducted drug discovery efforts, successfully identifying two potential inhibitors that could work against both host and pathogen SPL, opening possibilities for new antifungal treatments in CF patients.