Publications by authors named "T Zee"
Article Synopsis
- Skeletal muscles take time to produce force, which is influenced by several processes like calcium activation and cross-bridge cycling, but these have not been fully integrated in existing muscle models.
- Researchers examined how these processes contribute to force development in two common muscle models (Hill-type and cross-bridge) and found that neither could accurately recreate classic muscle data, indicating the need for additional dynamics like cooperative myofilament interactions.
- They proposed a new 'force facilitation dynamics' model that accurately represents force development across different excitations and highlighted that the main contributors to force dynamics in human quadriceps are largely attributed to these facilitation processes rather than calcium activation or cross-bridge cycling alone.*
Protein tyrosine phosphatase N2 (PTPN2) is a type 1 diabetes (T1D) candidate gene identified from human genome-wide association studies. PTPN2 is highly expressed in human and murine islets and becomes elevated upon inflammation and models of T1D, suggesting that PTPN2 may be important for β-cell survival in the context of T1D. To test whether PTPN2 contributed to β-cell dysfunction in an inflammatory environment, we generated a β-cell-specific deletion of Ptpn2 in mice (PTPN2-β knockout [βKO]).
View Article and Find Full Text PDFEven though there is a significant amount of scholarly work examining the ethical issues surrounding human genomics research, little is known about its footing in Malaysia. This study aims to explore the experience of local researchers and research ethics committee (REC) members in developing it in Malaysia. In-depth interviews were conducted from April to May 2021, and the data were thematically analysed.
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- In March 2023, the same disease was observed in a greenhouse nursery with 11 out of 481 plants affected.
- The rust fungus was identified through morphological analysis and molecular techniques, revealing a high genetic similarity to samples from Florida and Japan, and its pathogenicity was confirmed by USDA diagnostics.
The biomechanics of human walking are well documented for standard conditions such as for self-selected step length and preferred speed. However, humans can and do walk with a variety of other step lengths and speeds during daily living. The variation of biomechanics across gait conditions may be important for describing and determining the mechanics of locomotion.
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