Publications by authors named "T Yuki"
Article Synopsis
- Seborrheic keratosis (SK) is a common benign tumor linked to hyperpigmentation; this study examines the mechanisms behind melanin accumulation in SK through gene expression and histological analyses.
- Five pairs of skin samples were analyzed from three male participants, revealing abnormal cell proliferation and differentiation in SK, particularly in the basal and other layers of the epidermis.
- Although the number of melanocytes was higher in SK, the overall melanogenic activity remained unchanged; the study suggests melanin buildup is due to delayed excretion rather than increased production, offering insights for future treatments.
Introduction: Extracellular matrix (ECM) synthesis and deposition in fibroblasts, and vascularization via endothelial cells are essential for successful tissue regeneration. Fibroblasts can produce both ECM, physical support for maintaining homeostasis, and bioactive molecules, such as growth factors and cytokines. Endothelial cells can secrete growth factors and form vascular networks that enable the supply of nutrients and oxygen and remove metabolic products.
View Article and Find Full Text PDFAllergic contact dermatitis (ACD) and atopic dermatitis (AD) are common inflammatory diseases. We previously reported attenuated contact hypersensitivity (CHS) responses in AD model mice using 2,4-dinitrofluorobenzene, reflecting clinical experiments. However, previous studies have not addressed the commonality of findings across haptens and mechanisms focused on dendritic cells (DCs).
View Article and Find Full Text PDFThe Short Time Exposure (STE) test evaluates eye irritation potential using a 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. MTT assays may underpredict results for some substances that directly reduce MTT (i.e.
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