Publications by authors named "T Yu Kulagina"

Article Synopsis
  • The study aimed to examine the effects of polychemotherapy on cardiovascular biomarkers in 30 patients with newly diagnosed lymphomas, focusing on cardiotoxicity and heart function changes over six months.
  • Significant changes were observed in systemic inflammation markers, with C-reactive protein (CRP) and interleukin-6 (IL-6) levels decreasing, while biomarkers like endothelin-1 (ET-1) and ST-2 showed increases that were not statistically significant.
  • Despite alterations in diastolic heart function, there were no signs of cardiotoxicity affecting heart muscle contraction, suggesting that polychemotherapy did not adversely impact the patients' systolic function.
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Significant advances in timely diagnosis and modern antitumor therapy have led to a considerable increase in the survival rate of cancer patients. On the other hand, the incidence of cardiovascular (CV) diseases and their complications is increasingly growing, including due to side effects of anticancer drugs. CV complications are the most common cause of non-oncological death of cancer patients.

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Preoperative assessment should include spirometry and analysis of the diffusing capacity for carbon monoxide. If necessary, exercise tests can be performed. High risk patients can be revealed considering these data.

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Aim      To evaluate the right and left ventricular function and their interaction in patients with ischemic heart disease (IHD) complicated with mitral valve insufficiency (MVI) according to data of echocardiography (EchoCG) with the strain in gray scale, vector and diagram analyses.Material and methods  The study included 118 patients evaluated with EchoCG at the preoperative stage of treatment; 71 of these patients had ischemic MVI (group 1) and 47 patients had uncomplicated IHD (group 2 or comparison group). Mean age of patients was 64±10 years.

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We examined a total of 106 patients with ischaemic heart disease (mean age - 59±7 years) and 30 apparently healthy people (mean age - 36±4 years). Myocardial revascularization was performed with the help of stenting and coronary artery bypass grafting. The patients with ischaemic heart disease were divided into 2 groups: Group 1 with postinfarction cardiosclerosis and Group 2 without Q-forming myocardial infarction.

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