Publications by authors named "T Yoshinobu"
The monitoring of ion homeostasis in vivo is of paramount importance due to its critical functions in biological systems. However, current leading technologies for creating ion-selective electrodes often fall short of the requirements for in vivo applications in terms of multiplexity, miniaturization, and flexibility. To address this gap, we introduce an integrated multiplexed ion monitoring probe created from thermally drawn multi-electrode polymer fiber, aimed at enhancing in vivo ion homeostasis studies.
View Article and Find Full Text PDFA light-addressable potentiometric sensor (LAPS) is a semiconductor-based sensor platform for sensing and imaging of various chemical species. Being a potentiometric sensor, no faradaic current flows through its sensing surface, and no electrochemical reaction takes place in the course of LAPS measurement. In this study, a four-electrode system is proposed, in which a LAPS is combined with the conventional three-electrode electrochemical system.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated mortality trends and factors related to immunoglobulin G4-related disease (IgG4-RD) in patients with various organ involvement at a Japanese rheumatology center.
- A total of 179 patients were reviewed over a median follow-up of 47 months, revealing a standardized mortality ratio of 0.86, indicating that long-term survival is not significantly affected by IgG4-RD.
- Key factors linked to increased mortality included the number of affected organs at diagnosis, significant renal dysfunction (glomular filtration rate <45 ml/min), and the presence of malignancy during treatment, highlighting the importance of early detection and management.
Article Synopsis
- Bioelectronic devices are transitioning to more flexible materials, with thermally-drawn-fiber-based bioelectronics showing potential due to their flexibility and multifunctional integration.
- The research focuses on creating microelectrode fibers from carbon nanotube (CNT)-based composites, which have enhanced electrochemical sensitivity and compatibility for effective sensing.
- Tests demonstrated that these microelectrode fibers exhibit ultra-high sensitivity for detecting substances like ferrocenemethanol and dopamine, and they have potential for selective ion sensing, particularly for Na+ ions, making them promising for point-of-care applications.