Publications by authors named "T Yeghen"
Article Synopsis
- Fetal hemoglobin (HbF) plays a significant role in influencing the severity of sickle cell disease (SCD) and is linked to three common genetic loci.
- Researchers used statistical methods to analyze specific genetic variants related to HbF levels in patients with SCD, focusing on individuals aged 5 and older with relevant genotype and HbF data.
- Their findings narrowed down seven genetic variants to four significant markers that together explain approximately 21.8% of HbF variability in the study population, with results validated in two additional cohorts, highlighting the model's potential for future genetic research and clinical applications in SCD.
A 29-year-old woman presented with neutropenic sepsis and was found to have a new diagnosis of acute myeloid leukaemia. Following initiation of induction chemotherapy the patient became increasingly unwell with ongoing sepsis despite broad-spectrum antibiotic treatment. An extensive septic screen failed to identify a source, other than the finding of a peripancreatic mass on imaging.
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