Publications by authors named "T Yamagiwa"
Article Synopsis
- Posaconazole is important for treating fungal infections, but its pharmacokinetics (how the drug is processed in the body) can be influenced by factors such as HSCT, body weight, and diet.
- A study examined the factors affecting posaconazole levels in Japanese patients, finding that almost 30% had low drug levels below the effective range, especially in those who had undergone HSCT or experienced frequent diarrhea.
- The results suggest that monitoring posaconazole levels is crucial for patients, particularly after HSCT or during digestive issues, to prevent inadequate treatment of serious fungal infections.
Introduction: Cardiac arrest is a critical condition, and patients often experience postcardiac arrest syndrome (PCAS) even after the return of spontaneous circulation (ROSC). Administering a restricted amount of oxygen in the early phase after ROSC has been suggested as a potential therapy for PCAS; however, the optimal target for arterial partial pressure of oxygen or peripheral oxygen saturation (SpO) to safely and effectively reduce oxygen remains unclear. Therefore, we aimed to validate the efficacy of restricted oxygen treatment with 94%-95% of the target SpO during the initial 12 hours after ROSC for patients with PCAS.
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