Publications by authors named "T Y de Winter"
Article Synopsis
- Oxylipins, which are lipid mediators derived from fatty acids, play crucial roles in respiratory health, but their profiles in lung structural cells are not fully understood.
- The study measured 162 oxylipins in airway smooth muscle, lung fibroblasts, and epithelial cells, both at baseline and after exposure to various stimuli.
- Results showed that airway smooth muscle and lung fibroblasts had similar oxylipin profiles dominated by CYP450 metabolites, while epithelial cells had a unique profile rich in COX-derived oxylipins, with distinct changes noted upon stimulation that could impact respiratory function.
It was once believed that only microbes and viruses inhabited the subseafloor crust beneath hydrothermal vents. Yet, on the seafloor, animals like the giant tubeworm Riftia pachyptila thrive. Their larvae are thought to disperse in the water column, despite never being observed there.
View Article and Find Full Text PDFBackground: The dietary requirement for α-linolenic acid (ALA) remains unclear, as evidenced by the absence of a Recommended Dietary Allowance (RDA) for this essential fatty acid (FA). In previous studies, we observed that the amount of dietary ALA required to maximize nonesterified (NE) DHA oxylipins appears to be higher than the amount required to maximize tissue esterified DHA, which have classically been used to estimate the ALA requirement. Further, we observed that dietary ALA reduces esterified arachidonic acid (ARA) and its NE oxylipins.
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- The study explored how vitamin D levels affect inflammation markers in children and teens across eight European countries.
- Researchers found that higher vitamin D levels were linked to increased levels of adiponectin and reduced inflammation scores, particularly in children with normal weight.
- In overweight or obese children, only a positive connection to one marker (IP-10) was seen, highlighting the need for weight management to see improvements in inflammation related to vitamin D.
We performed a series of integrative analyses including transcriptome-wide association studies (TWASs) and proteome-wide association studies (PWASs) of renal cell carcinoma (RCC) to nominate and prioritize molecular targets for laboratory investigation. On the basis of a genome-wide association study (GWAS) of 29,020 affected individuals and 835,670 control individuals and prediction models trained in transcriptomic reference models, our TWAS across four kidney transcriptomes (GTEx kidney cortex, kidney tubules, TCGA-KIRC [The Cancer Genome Atlas kidney renal clear-cell carcinoma], and TCGA-KIRP [TCGA kidney renal papillary cell carcinoma]) identified 38 gene associations (false-discovery rate <5%) in at least two of four transcriptomic panels and identified 12 genes that were independent of GWAS susceptibility regions. Analyses combining TWAS associations across 48 tissues from GTEx identified associations that were replicable in tumor transcriptomes for 23 additional genes.
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