CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety.

CDK4/6 inhibitors have revolutionized treatment of hormone receptor positive (HR+), HER2 non-amplified (HER2-) breast cancer. Yet, all "dual" CDK4/6 inhibitors show common dose-limiting hematologic toxicities, foremost neutropenia. This poses challenges to provide these agents at concentrations necessary to extinguish cell cycling in tumors.

Phenotype of pheochromocytoma and paraganglioma by germline mutation: a Korean multicenter study.

Recent advances in genetic testing have challenged the traditional genotype-phenotype correlation in pheochromocytomas and paragangliomas (PPGL). We aimed to characterize the genotype-phenotype correlations in PPGL in a large Korean cohort and compare our findings with those from other countries. We retrospectively analyzed 627 patients with PPGL from two centers, who underwent genetic testing for germline pathogenic variants (PV) from 2000-2023, to examine the prevalence of clusters and their correlation with specific phenotypes.

Postoperative outcomes in normotensive and hypertensive pheochromocytomas: an international study.

Introduction: Postoperative outcomes of patients with normotensive pheochromocytomas are poorly documented. We aimed to evaluate the impact of preoperative hypertension on post-operative outcomes following adrenalectomy for pheochromocytoma.

Methods: An international retrospective study of patients undergoing adrenalectomy for pheochromocytoma in 46 centers between 2012-2022 was performed.

Impacts of Avoiding Emergency Department Visits During the COVID-19 Pandemic Among Patients With Acute Ischemic Heart Events.

Purpose: The COVID-19 pandemic significantly disrupted healthcare services as individuals avoided medical facilities to reduce the risk of infection. Despite Taiwan's effective public health measures and low SARS-CoV-2 case numbers in 2020, emergency department (ED) utilization patterns still changed, particularly for cases with acute ischemic heart events. This study investigated how the pandemic influenced medical avoidance in such cases and assessed potential collateral damage and adverse outcomes in an ED that managed limited COVID-19 instances during this period.

Strategic carbon source supplementation enhances nitrite degradation by Pantoea sp. A5 in variable temperature conditions.

The expanding global demand for sustainable aquaculture underscores the need for efficient water quality management, particularly in controlling harmful nitrogenous compounds like nitrites. This study explores the effectiveness of Pantoea sp. A5, a nitrite-degrading bacterium isolated from food waste, reduces nitrite levels in aquaculture systems, focusing on the role of carbon sources like glucose and glycerol.