Publications by authors named "T Y Prudnikova"
The first Federation of European Biochemical Societies Advanced Course on macromolecular crystallization was launched in the Czech Republic in October 2004. Over the past two decades, the course has developed into a distinguished event, attracting students, early career postdoctoral researchers and lecturers. The course topics include protein purification, characterization and crystallization, covering the latest advances in the field of structural biology.
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- A limited number of innovative antibacterial agents are being developed to effectively target critical Gram-negative bacteria resistant to current treatments, with endolysins showing promise due to their unique action against these pathogens.
- The study uses a multidisciplinary approach including genetic engineering, structural analysis, and various formulations of the engineered endolysin LysECD7-SMAP, which are tested for effectiveness in preclinical models of infections such as sepsis and pneumonia.
- Results indicate that LysECD7-SMAP is effective against multiple drug-resistant bacteria, and in vivo studies confirm the efficacy of its formulated dosage forms, along with insights into how it interacts with bacterial cell walls.
Genetic studies indicate that breast cancer can be divided into several basic molecular groups. One of these groups, termed IntClust-2, is characterized by amplification of a small portion of chromosome 11 and has a median survival of only five years. Several cancer-relevant genes occupy this portion of chromosome 11, and it is thought that overexpression of a combination of driver genes in this region is responsible for the poor outcome of women in this group.
View Article and Find Full Text PDFConformational transition of the Ixodes ricinus salivary serpin Iripin-4.
Acta Crystallogr D Struct Biol
May 2023
Iripin-4, one of the many salivary serpins from Ixodes ricinus ticks with an as-yet unexplained function, crystallized in two different structural conformations, namely the native partially relaxed state and the cleaved serpin. The native structure was solved at a resolution of 2.3 Å and the structure of the cleaved conformation was solved at 2.
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- Some bacteria can make mammals sick by infecting their lungs, and one type causes a bad cough called whooping cough.
- Scientists studied a protein called BopN in a bacteria that causes this cough, finding it helps control how the bacteria injects harmful proteins into the cells it infects.
- They discovered that BopN acts like a gatekeeper, deciding if and when the bacteria can release these proteins based on the environment around it, helping the bacteria avoid being attacked by the body's defense system.