Thermally Triggered Double Emulsion-Integrated Hydrogel Microparticles for Multiplexed Molecular Diagnostics.

During the COVID-19 pandemic, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) has been recognized as the most reliable diagnostic tool. However, there is a need to develop multiplexed assays capable of analyzing multiple genes simultaneously to expand its application. To address this, a multiplexed RT-qPCR using a double emulsion (DE)-based carrier and a polymer microparticle reactor, termed primer-incorporated network tailored with Taqman probe (TaqPIN) is developed.

Conversion Therapy for Stage IV Gastric Cancer: Report From the Expert Consensus Meeting at KINGCA WEEK 2024.

Conversion therapy is a treatment strategy that shifts from palliative systemic therapy to curative surgical treatment for primary and/or metastatic stage IV gastric cancer (GC). To address its clinical statements, the Korean Gastric Cancer Association aims to present a consensus on conversion therapy among experts attending KINGCA WEEK 2024. The KINGCA Scientific Committee and Development Working Group for Korean Practice Guidelines prepared preformulated topics and 9 clinical statements for conversion therapy.

Korean Practice Guidelines for Gastric Cancer 2024: An Evidence-based, Multidisciplinary Approach (Update of 2022 Guideline).

Gastric cancer is one of the most common cancers in both Korea and worldwide. Since 2004, the Korean Practice Guidelines for Gastric Cancer have been regularly updated, with the 4th edition published in 2022. The 4th edition was the result of a collaborative work by an interdisciplinary team, including experts in gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology, and guideline development methodology.

Long-term changes in gingival recessions and their impact on oral health-related quality of life in patients under supportive periodontal therapy: a bidirectional cohort study.

Objectives: To evaluate changes in gingival recessions (GR) in periodontitis patients over ten years of supportive periodontal therapy (SPT) and to assess the impact of GR on oral health-related quality of life (OHRQoL).

Materials And Methods: Fifty-one patients with over ten years of SPT were followed up (V1) with complete periodontal status including periodontal probing depth (PPD) and clinical attachment level (CAL) at 6 sites/tooth, oral hygiene indices, and recession status. Patient anamnesis, oral hygiene habits, and orthodontic history were assessed.

Development and Validation of a Machine Learning Method Using Vocal Biomarkers for Identifying Frailty in Community-Dwelling Older Adults: Cross-Sectional Study.

Background: The two most commonly used methods to identify frailty are the frailty phenotype and the frailty index. However, both methods have limitations in clinical application. In addition, methods for measuring frailty have not yet been standardized.