Publications by authors named "T Xenitidis"
Article Synopsis
- * The main symptoms include recurrent oral and genital ulcers, skin lesions, and eye issues, which can lead to severe complications, requiring collaboration among various medical specialties.
- * Recent advancements in treatment include the 2018 EULAR guidelines and the approval of medications like adalimumab and apremilast for specific symptoms, though there is still a need for new treatment options.
Article Synopsis
- Behçet's syndrome (BS) is a rare vasculitis that affects blood vessels of various sizes, presenting challenges in both diagnosis and treatment due to its diverse symptoms, including oral and genital ulcers, skin, and eye lesions.
- The management of BS has been guided by updated recommendations from the European League Against Rheumatism (EULAR), with treatments like adalimumab and apremilast recently approved for specific symptoms.
- This article focuses on recent advancements in understanding Behçet's syndrome through epidemiology, immunopathogenesis, genetics, clinical features, and therapeutic approaches, highlighting their clinical significance.
Background: The purpose of this trial was to evaluate the effectiveness and safety of the IL-6 receptor antibody Tocilizumab (TCZ) in the treatment of Familial Mediterranean Fever (FMF). Methods: This was a randomized, double-blinded, placebo-controlled phase II trial in adult patients with active FMF and an inadequate response or intolerance to colchicine (crFMF). The physician’s global assessment of disease activity (PGA), based on a five-point scale for six symptoms, was used as a clinical score, which had to be >2 at screening, together with elevated c-reactive protein (CRP) or erythrocyte sedimentation rate (ESR) and serum amyloid A (SAA) levels, to be eligible for inclusion.
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