Comparison of antegrade and retrograde laparoscopic bilateral inguinal lymphadenectomy for penile cancer.

Purpose: To investigate and compare the feasibility, safety, and clinical outcomes of antegrade and retrograde laparoscopic bilateral inguinal lymphadenectomy for penile cancer.

Methods: We retrospectively analyzed the clinical data of 32 patients with penile cancer admitted between 2018 and 2022. Among them, 17 patients underwent antegrade laparoscopic inguinal lymphadenectomy (ALIL group) and 15 underwent retrograde laparoscopic inguinal lymphadenectomy (RLIL group).

Influence of continuous fertilization on heavy metals accumulation and microorganism communities in greenhouse soils under 22 years of long-term manure organic fertilizer experiment.

This study examined the impact of long-term manure organic fertilizer application (3, 8, 13, 18, and 22 years) on soil physicochemical properties, heavy metal (HM) accumulation, and microbial communities. Long-term manure application markedly elevated nutrient levels such as available N, P and K, and organic matter content in surface and soil profile. Total and DTPA-HM content in different vertical profiles increased with the application time.

Development and characterization of a novel injectable thyroid extracellular matrix hydrogel for enhanced thyroid tissue engineering applications.

Hypothyroidism, a condition characterized by decreased synthesis and secretion of thyroid hormones, significantly impacts intellectual development and physical growth. Current treatments, including hormone replacement therapy and thyroid transplantation, have limitations due to issues like hormone dosage control and immune rejection. Tissue engineering presents a potential solution by combining cells and biomaterials to construct engineered thyroid tissue.

Ototoxic effects of unilateral postauricular neomycin administration on the inner ears of Guinea pigs.

Backgrounds: Due to the therapeutic needs of inner ear diseases, a simple method of inner ear drug delivery has been under exploration. Postauricular administration, which involves injecting the drug through the middle of the retroauricular groove, is a potential novel approach, but its mechanisms remain unclear.

Objectives: To investigate threshold shifts in the auditory brainstem response (ABR), as well as the morphology and quantity of hair cells on the bilateral inner ear of guinea pigs after postauricular neomycin administration.

Implications of the NDC80 complex on the tumor immune microenvironment and cell growth in pan-cancer.

Previous evidence indicates that the NDC80 complex, a conserved spindle microtubule-binding component of the kinetochore, is overexpressed and associated with prognosis in certain cancer types. Herein, we assessed the expression and prognostic value of NDC80 complex components in pan-cancer and interrogated their potential functions in tumor context through multiple databases and software. Our findings showed that the expression of NDC80 complex components was aberrant across almost all cancer types and correlated positively with poor prognosis at the pan-cancer level.