Publications by authors named "T Willmott"
Article Synopsis
- The oral microbiome's composition is affected by environmental factors in chronic kidney disease (CKD) and after kidney transplantation, particularly influenced by urea levels in saliva.
- The study modeled the effects of varying urea concentrations in saliva across different phases: healthy, CKD, and post-transplant, using artificial saliva and observing microbial changes over time.
- Findings revealed stability in microbial communities despite urea fluctuations, with notable increases in certain bacteria (like TG5) in late stages, highlighting the complex relationship between salivary urea and oral health in kidney conditions.
Article Synopsis
- The study assessed the effects of different quaternary ammonium biocides (QUATs) on 10 microbial strains relevant to hygiene, focusing on their antimicrobial potency and potential for developing resistance.
- Biocide mixtures were found to be more effective than singular and formulated biocides, with some strains showing significant changes in susceptibility after exposure.
- Although there were adaptations in the bacteria exposed to singular biocides, the overall impact on antibiotic resistance and genetic mutations was limited, suggesting formulated QUATs might present a lower risk for developing antimicrobial resistance.
The generation of nitrite by the oral microbiota is believed to contribute to healthy cardiovascular function, with oral nitrate reduction to nitrite associated with systemic blood pressure regulation. There is the potential to manipulate the composition or activities of the oral microbiota to a higher nitrate-reducing state through nitrate supplementation. The current study examined microbial community composition and enzymatic responses to nitrate supplementation in sessile oral microbiota grown in continuous culture.
View Article and Find Full Text PDFDuring pregnancy, all major physiological systems undergo remarkable changes, driven largely by alterations in the maternal hormonal milieu. In healthy pregnancies, maternal cardiovascular and metabolic adaptation to pregnancy occurs to support fetal growth and maternal well-being. Impaired maternal adaptation to pregnancy is associated with a range of pregnancy complications, including gestational diabetes and preeclampsia.
View Article and Find Full Text PDFBackground: The efficacy of dietary nitrate supplementation to lower blood pressure (BP) in pregnant women is highly variable. We aimed to investigate whether differences in oral microbiota profiles and oral nitrate-reducing capacity may explain interindividual differences in BP lowering following nitrate supplementation.
Methods: Participants recruited for this study were both pregnant and nonpregnant women, with or without hypertension (n=55).