Publications by authors named "T Wiggen"
Article Synopsis
- This study investigates how chronic lung diseases influence the development of chronic lung allograft dysfunction (CLAD) in lung transplant recipients, focusing on the molecular and microbial changes in their bronchoalveolar lavage fluid (BALF).
- Researchers analyzed BALF samples from 195 lung transplant patients over 10 years using advanced sequencing and metabolomics techniques, revealing significant differences in microbiome and metabolome profiles based on the underlying lung disease.
- Results show that specific microbial species like Pseudomonas in cystic fibrosis and unique metabolites in alpha-1-antitrypsin disease correlate with CLAD development, suggesting that tailored treatment strategies could improve long-term outcomes for lung transplant patients.
Article Synopsis
- The study investigates how metformin use in adults with type 2 diabetes may impact the incidence of postacute sequelae of SARS-CoV-2 (PASC) and death after COVID-19 infection.
- Findings indicate that metformin users had a lower risk of death and PASC compared to those on other diabetes medications, with hazard ratios suggesting reduced incidence in the National COVID Cohort Collaborative (N3C).
- The results support previous observations that metformin may lead to better outcomes post-COVID-19, although the incidence of PASC was notably higher when assessed with computable phenotypes compared to EHR codes.
Objective: The coronavirus 2019 (COVID-19) pandemic has evolved over time by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, disease severity, treatment, and prevention. There is evidence of an elevated risk of incident diabetes after COVID-19; our objective was to evaluate whether this association is consistent across time and with contemporary viral variants.
Research Design And Methods: We conducted a retrospective cohort study using National COVID Cohort Collaborative (N3C) data to evaluate incident diabetes risk among COVID-positive adults compared with COVID-negative patients or control patients with acute respiratory illness (ARI).
Different effector arms of the immune system are optimized to protect from different classes of pathogens. In some cases, pathogens manipulate the host immune system to promote the wrong type of effector response-a phenomenon known as immune deviation. Typically, immune deviation helps pathogens to avoid destructive immune responses.
View Article and Find Full Text PDFBackground: Monitoring COVID-19 infection risk among health care workers (HCWs) is a public health priority. We examined the seroprevalence of SARS-CoV-2 among HCWs following the fall infection surge in Minnesota, and before and after COVID-19 vaccination. Additionally, we assessed demographic and occupational risk factors for SARS-CoV-2 infection.
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