Colonic permeability is increased in non-cirrhotic patients with nonalcoholic fatty liver disease.

Background And Aim: Intestinal permeability (IP) plays an important role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). We assessed site-specific (gastroduodenum, small intestine, colon and whole gut) IP in NAFLD patients and healthy controls (HC) and its association with the degree of hepatic steatosis, hepatic fibrosis and dietary composition in these NAFLD patients.

Methods: In vivo site-specific IP was analysed with a validated multi-sugar test in NAFLD patients and HC.

Developing a patient portal for haematology patients requires involvement of all stakeholders and a customised design, tailored to the individual needs.

Background: Electronic patient portals are increasingly being implemented, also in (haemato) oncology. However, portal usage is low and depends on user and provider engagement. We explored wishes, expectations and thoughts of patients with a haematologic malignancy and their physicians with regard to the electronic patient portal.

All-polymer photonic sensing platform based on whispering-gallery mode microgoblet lasers.

We present an all-polymer photonic sensing platform based on whispering-gallery mode microgoblet lasers integrated into a microfluidic chip. The chip is entirely made from polymers, enabling the use of the devices as low-cost disposables. The microgoblet cavities feature quality factors exceeding 10(5) and are fabricated from poly(methyl methacrylate) (PMMA) using spin-coating, mask-based optical lithography, wet chemical etching, and thermal reflow.

Densely Packed Microgoblet Laser Pairs for Cross-Referenced Biomolecular Detection.

Parallel readout of the micro-lasers facilitates effective mutual filtering of highly localized refractive index and temperature fluctuations in the analyte. Cross-referenced detection of two different types of proteins and complete chemical transducer reconfiguration is demonstrated. Selective surface functionalization of the individual lasers with high spatial accuracy is achieved by aligned microcontact stamping.

Efficient free-space read-out of WGM lasers using circular micromirrors.

Lasing from whispering-gallery mode (WGM) resonators occurs omnidirectional in azimuthal plane. Most applications of WGM resonators require spectral analysis with off-chip detectors, where in-plane emission and beam divergence hinder efficient detection. We demonstrate redirecting WGM laser emission from all azimuthal angles using a circular micromirror placed around the cavity.