1H and 13C NMR characteristics of the anticancerous derivative of acridine: Ledakrin C-283 (nitracrine).

For the anticancerous derivative of acridine--Ledakrin C-283 [1-nitro-9-(3-dimethylaminopropylamino)-acridine . 2HCl-H2O] 1H and 13C NMR spectra were assigned and analysed with particular emphasis on pH effects. On pH increase in 2H2O, the deprotonation of N(10) in Ledakrin aromatic core causes a high and selective upfield shift of the resonances for aromatic protons and strong deshielding for aromatic carbons C(11)-C(14), especially those adjacent to N(10).