Publications by authors named "T Wiebe"
Aims: The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in this cohort.
Methods And Results: Fifty-seven CCS and 53 healthy controls (age 20-30 years) were studied. Plasma long-chain ceramides, known to be cardiotoxic (C16:0, C18:0, C24:0, and C24:1), were analysed by mass spectrometry.
Purpose: Childhood cancer survivors, in particular those treated with radiation therapy, are at high risk of long-term iatrogenic events. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. We aimed to set up a standardized organ dose table to help former patients and clinicians in charge of long-term follow-up clinics.
View Article and Find Full Text PDFIntroduction: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclinical cardiovascular disease.
View Article and Find Full Text PDFBackground: Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort.
Methods: Using data from 69,460 5-year childhood cancer survivors (diagnosed 1940-2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated.
Article Synopsis
- Radiation exposure to bone tissue in childhood cancer survivors is linked to an increased risk of bone cancer, with a stronger correlation observed for doses above 1 Gy.
- A study of 228 cases and controls from 12 European countries found significant odds ratios for bone cancer related to radiation doses of 1-9 Gy and high cumulative doses of alkylating agents.
- The findings highlight the need to revise clinical follow-up guidelines for childhood cancer survivors due to the increased risks, especially for specific chemotherapy drugs like procarbazine, ifosfamide, and cyclophosphamide.