Publications by authors named "T Wassenberg"
(3-(pyrimidin-4-yl)-7-azaindoles) are synthetic hybrids of the naturally occurring alkaloids and and display a strong cytotoxic potential. We have recently shown that the novel derivative is highly cytotoxic in several lymphoma and leukemia cell lines as well as in primary patient-derived lymphoma and leukemia cells and predominantly targets cyclin-dependent kinases (CDKs). Here, we efficiently synthesized nine novel 2-aminopyridyl congeners (-), i.
View Article and Find Full Text PDFAbout 100,000 deaths are attributed annually to infections with methicillin-resistant (MRSA) despite concerted efforts toward vaccine development and clinical trials involving several preclinically efficacious drug candidates. This necessitates the development of alternative therapeutic options against this drug-resistant bacterial pathogen. Using the Masuda borylation-Suzuki coupling (MBSC) sequence, we previously synthesized and modified naturally occurring bisindole alkaloids, alocasin A, hyrtinadine A and scalaradine A, resulting in derivatives showing potent and antibacterial efficacy.
View Article and Find Full Text PDFCorrigendum to: Prevalence of DDC genotypes in patients with aromatic L-amino acid decarboxylase (AADC) deficiency and in silico prediction of structural protein changes.
Mol Genet Metab
August 2023
Article Synopsis
- AADC deficiency is a rare genetic disorder that impacts the production of neurotransmitters like dopamine, norepinephrine, epinephrine, and serotonin, diagnosed via CSF/plasma analysis, AADC activity measurement, and genetic testing for the DDC gene.
- In a study involving 348 patients, researchers identified 26 new DDC variants and analyzed their prevalence, finding that a specific splice variant, c.714+4A>T, was the most common, particularly prevalent in Taiwan and China.
- The majority of identified genotypes were classified as pathogenic or likely pathogenic, with only one benign variant reported, and most AADC protein variants impacted protein function significantly based on their structural characteristics.*
Patients with double stranded DNA repair disorders (DNARDs) (Ataxia Telangiectasia (AT) and Nijmegen Breakage syndrome (NBS)) are at a very high risk for developing hematological malignancies in the first two decades of life. The most common neoplasms are T-cell lymphoblastic malignancies (T-cell ALL and T-cell LBL) and diffuse large B cell lymphoma (DLBCL). Treatment of these patients is challenging due to severe complications of the repair disorder itself (e.
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