XRCC1 Arg399Gln gene polymorphism and the risk of systemic lupus erythematosus in the Polish population.

It has been shown that DNA repair is reduced in patients with systemic lupus erythematosus (SLE) and that the X-ray repair cross-complementing (XRCC1) Arg399Gln (rs25487) polymorphism may contribute to DNA repair. We evaluated the frequency of the XRCC1 Arg399Gln substitution in patients with SLE (n=265) and controls (n=360) in a sample of the Polish population. The odds ratio (OR) for SLE patients with the Gln/Gln versus Gln/Arg or Arg/Arg genotypes was 1.

Interleukin-18 promoter polymorphisms in patients with systemic lupus erythematosus.

Objectives: The role of various polymorphisms located in the IL-18 promoter has not yet been defined with regards to patient susceptibility to SLE, and occurrence of clinical manifestations of the disease remains inconsistent.

Methods: Using PCR-RFLP and DNA sequencing analysis we studied the frequency of -137 G/C (rs187238), -607 C/A (rs1946518) and -1297C/T (rs360719) polymorphisms in IL-18 promoter in patients with SLE from a sample of the Polish population.

Results: We observed that patients with SLE bearing the IL-18 -1297CC genotype exhibited a 2.

Distribution of CCND1 A870G polymorphism in patients with advanced uterine cervical carcinoma.

We examined the distribution of the CCND1 A870G (rs9344) polymorphic variant in patients with cervical cancer (n = 129) and healthy individuals (n = 288) in a sample of a Polish cohort. We showed that patients with advanced cervical cancer bearing the CCND1 A/A and A/G genotypes displayed a 1.811-fold increased risk of cervical cancer (95% CI = 1.

ITGAM Arg77His is associated with disease susceptibility, arthritis, and renal symptoms in systemic lupus erythematosus patients from a sample of the Polish population.

The ITGAM Arg77His (rs1143679) and Ala858Val (rs1143683) polymorphisms have been found to be strong contributors to systemic lupus erythematosus (SLE) development. There are evident population distinctions in terms of SLE distribution and manifestations; therefore, we investigated the distribution of the ITGAM Arg77His and Ala858Val polymorphisms in patients with SLE (n = 154) and control subjects (n = 276) in a sample of the Polish population. We observed that patients with the ITGAM His/His and Arg/His genotypes displayed a 1.

SDF1-3' G801A polymorphisms in Polish patients with systemic lupus erythematosus.

It has been reported that stromal cell-derived factor-1 (SDF1), currently also designated CXCL12, plays a significant role in the development of nephritis and death in the lupus mice model. Using restriction length fragment polymorphism (RFLP) analysis we assessed the frequencies of SDF1-3' G801A (rs 1801157) polymorphic variants between systemic lupus erythematosus (SLE) patients (n = 150) and controls (n = 300). There were no significant differences in the prevalence of SDF1-3' G801A polymorphic variants in SLE patients and healthy individuals.