Publications by authors named "T W de Graaf"

Article Synopsis
  • Spatial attention control is managed by specialized functions in both brain hemispheres, resulting in asymmetries that can be studied through hemineglect cases and TMS in healthy individuals.
  • Neuropsychological models, particularly Kinsbourne's opponent processor model and Heilman's hemispatial model, offer differing predictions about how unilateral disruption of the posterior parietal cortex (PPC) affects attention.
  • A meta-analysis of ten studies revealed that while PPC disruption led to impairments in the contralateral hemifield, there was no evidence of ipsilateral enhancement, challenging existing theories and suggesting a need to re-evaluate models of attention in research and therapeutic settings.
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Hemispheric asymmetry is a fundamental principle in the functional architecture of the brain. It plays an important role in attention research where right hemisphere dominance is core to many attention theories. Lesion studies seem to confirm such hemispheric dominance with patients being more likely to develop left hemineglect after right hemispheric stroke than vice versa.

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Recently it has been discovered that visuospatial attention operates rhythmically, rather than being stably employed over time. A low-frequency 7-8 Hz rhythmic mechanism coordinates periodic windows to sample relevant locations and to shift towards other, less relevant locations in a visual scene. Rhythmic sampling theories would predict that when two locations are relevant 8 Hz sampling mechanisms split into two, effectively resulting in a 4 Hz sampling frequency at each location.

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Parkinson's disease (PD) is a movement disorder caused by degeneration in dopaminergic neurons. During the disease course, most of PD patients develop mild cognitive impairment (PDMCI) and dementia, especially affecting frontal executive functions. In this study, we tested the hypothesis that PDMCI patients may be characterized by abnormal neurophysiological oscillatory mechanisms coupling frontal and posterior cortical areas during cognitive information processing.

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The human brain has limited storage capacity often challenging the encoding and recall of a long series of multiple items. Different encoding strategies are therefore employed to optimize performance in memory processes such as chunking where particular items are 'grouped' to reduce the number of items to store artificially. Additionally, related to the position of an item within a series, there is a tendency to remember the first and last items on the list better than the middle ones, which calls the "serial position effect".

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