Enhanced crude oil degradation observed in sea ice following bioaugmentation with arctic bacteria.

Petroleum-derived contamination is a growing hazard for the Arctic Ocean and northern marine transportation corridors. In northern settings where the accessibility to oil spills can be limited, natural attenuation is the most promising remediation process. The goal of the presented research is to evaluate the impact of biodegradation on crude oil inside sea ice.

FDG PET/CT Scan Still Can Help in Evaluation of Prostate Cancer.

Although 18F-FDG PET/CT scan is not the preferred modality to evaluate prostate cancer patients due to generally low uptake of FDG in prostate cancer cells, it can still be helpful in some selected cases with diagnostic dilemma. Here we are presenting an unusual prostate cancer case, status post radical prostatectomy, with heterogenous uptake in osseous lesions on 68Ga-PSMA PET/CT scan and low PSA values. He was referred for further evaluation with 18F-FDG PET/CT scan, revealing widely metastatic lesions in bone and liver, in addition to mildly avid recurrence in prostatectomy surgical bed and also metastasis in the spleen.

Linking Phosphoinositides to Proteins: A Novel Signaling PIPeline.

Phosphoinositide (PIP) signaling plays pivotal roles in myriad biological processes and is altered in many diseases including cancer. Canonical PIP signaling involves membrane-associated PIP lipid second messengers that modulate protein recruitment and activity at membrane focal points. In the nucleus, PIP signaling operates separately from membranous compartments defining the paradigm of non-canonical PIP signaling.

Microbiome impact of ibezapolstat and other infection relevant antibiotics using humanized mice.

Background: Ibezapolstat (IBZ) is a competitive inhibitor of the bacterial Pol IIIC enzyme in clinical development for treatment of infection (CDI). Previous studies demonstrated IBZ carries a favorable microbiome diversity profile compared to vancomycin (VAN). However, head-to-head comparisons with other CDI antibiotics have not been done.

Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma.

Background: Subacute and chronic subdural hematomas are common and frequently recur after surgical evacuation. The effect of adjunctive middle meningeal artery embolization on the risk of reoperation remains unclear.

Methods: In a prospective, multicenter, interventional, adaptive-design trial, we randomly assigned patients with symptomatic subacute or chronic subdural hematoma with an indication for surgical evacuation to undergo middle meningeal artery embolization plus surgery (treatment group) or surgery alone (control group).