Publications by authors named "T W Van der Vaart"
Article Synopsis
- Staphylococcus aureus is a leading cause of severe healthcare-related infections, and existing antibiotic treatments often have high mortality rates, necessitating new treatment approaches.
- Researchers studied blood samples from 17 S. aureus bacteremia patients to analyze immune responses by isolating plasmablasts and sequencing their antibody genes, resulting in the identification of over 300 unique antibody sequences.
- Four novel monoclonal antibodies (mAbs) were developed, with one specifically targeting wall teichoic acid in S. aureus, while three showed cross-reactivity with Staphylococcus epidermidis and were able to trigger immune cell phagocytosis of staphylococci.
Article Synopsis
- The study aimed to assess whether short-term treatment with lamotrigine can enhance cognitive functioning in adolescents with neurofibromatosis type 1 (NF1).
- A double-blind, randomized clinical trial involved 31 participants aged 12 to 17 taking 200 mg of lamotrigine for 26 weeks, measuring outcomes like performance IQ and various cognitive skills.
- Results indicated that lamotrigine did not significantly affect overall cognitive performance or most secondary outcomes, with only a slight trend towards improved visual sustained attention noted in the treatment group.
Staphylococcus aureus is a major human pathogen, yet the immune factors that protect against infection remain elusive. High titers of opsonic IgG antibodies, achieved in preclinical animal immunization studies, have consistently failed to provide protection in humans. Here, we investigate antibody responses to the conserved S.
View Article and Find Full Text PDFPurpose: IDH-mutant glioma is classified as oligodendroglioma or astrocytoma based on 1p19q-codeletion. Whether prognostic factors are similar between these tumor types is not well understood.
Experimental Design: Retrospective cohort study.
Article Synopsis
- The study aimed to identify risk factors for acute kidney injury (AKI) and assess its impact on mortality in patients with Staphylococcus aureus bacteraemia (SAB), considering variables like recurrent AKI episodes and competing risks.
- A total of 453 patients were analyzed, revealing that 43% experienced AKI episodes, with age, comorbidity, septic shock, persistent bacteraemia, and vancomycin therapy linked to an increased AKI risk.
- The findings highlighted that AKI significantly raises the risk of 90-day mortality in SAB patients, indicating a worse clinical outcome than previously understood, especially in those treated with vancomycin.