Publications by authors named "T W McGowan"
Article Synopsis
- This study reviews trends in buprenorphine use in emergency departments (EDs) from 2014 to 2021 to understand its role in reducing opioid overdose risks and improving treatment access.
- There were nearly 342,000 ED visits with administered buprenorphine, showing no significant change over time, but a notable increase (233%) in buprenorphine prescriptions at discharge between 2019 and 2020.
- The findings suggest EDs served as crucial support for addiction treatment during the COVID-19 pandemic, highlighting a need for further research on the barriers to buprenorphine use.
Proteogenomics is a growing "multi-omics" research area that combines mass spectrometry-based proteomics and high-throughput nucleotide sequencing technologies. Proteogenomics has helped in genomic annotation for organisms whose complete genome sequences became available by using high-throughput DNA sequencing technologies. Apart from genome annotation, this multi-omics approach has also helped researchers confirm expression of variant proteins belonging to unique proteoforms that could have resulted from single-nucleotide polymorphism (SNP), insertion and deletions (Indels), splice isoforms, or other genome or transcriptome variations.
View Article and Find Full Text PDFAim: Childhood stroke has an estimated incidence of 2-13 per 100 000 children. Limited consensus exists regarding best practice recommendations for childhood stroke rehabilitation. A retrospective study completed at a tertiary institution identified potential associations between factors including type of stroke, functional presentation, muscle strength and length of stay (LOS).
View Article and Find Full Text PDFPurpose: Approximately 25% to 50% of patients with high-risk localized prostate cancer experience biochemical recurrence (BCR) within 2 years of radical prostatectomy. The Apa-RP study (NCT04523207) investigated whether adjuvant apalutamide plus androgen deprivation therapy (ADT) in high-risk patients who have undergone radical prostatectomy improved BCR-free survival.
Materials And Methods: Apa-RP was a multicenter, open-label, single-arm, phase 2 study conducted in community urology practices in the US.
Background: Patients from ethnic and racial minority groups with primary hyperparathyroidism may have greater time delays to curative parathyroidectomy. Contributing factors are unclear.
Methods: This was a sequential mixed-methods study.