Publications by authors named "T W Mak"
NIST Mass Spectral Libraries in the Context of the Circular Economy of Plastics.
J Am Soc Mass Spectrom
January 2025
Article Synopsis
- The Mass Spectrometry Data Center (MSDC) is enhancing libraries for identifying plastics-related compounds (PRC) and materials (PRM) as part of NIST's circular economy initiative.
- To increase the diversity of compounds analyzed, MSDC is utilizing three ionization methods: EI, ESI, and APCI, along with pyrolysis-gas chromatography (py-GC-MS) for solid materials.
- Collaborating with agencies like the FDA and EPA, they are testing these libraries to address health risks and environmental issues concerning plastics.
Alcohol use attenuates successful smoking cessation. We examined the feasibility, acceptability, and preliminary efficacy of a brief alcohol intervention in smokers. In this two-arm, assessor-blinded randomized controlled trial, we randomized 100 daily smokers (82.
View Article and Find Full Text PDFCancer associated fibroblasts (CAFs) are the predominant stromal cells in the tumor microenvironment of gastric cancer (GC), interacting with both immune and tumor cells to drive cancer progression. However, the precise link between these interactions and their potential as therapeutic targets remains poorly understood. In this study, we identified for the first time that nicotinamide N-methyltransferase (NNMT) derived from CAFs promoted M2 macrophage polarization, which, in turn, facilitated the proliferation and migration of GC cells.
View Article and Find Full Text PDFObjective: Since large food portion sizes (PS) lead to overconsumption, our objective was to review PS recommendations for commonly consumed food groups reported in Food-Based Dietary Guidelines (FBDGs) globally and to assess variation in PS across countries and regions.
Methods: Consumer-oriented FBDGs from the Food and Agriculture Organization (FAO) online repository were used to evaluate dietary recommendations, PS and number of portions for common food groups. Guidelines were classified for each group as qualitative, quantitative, or missing.
The discovery and identification of molecules in biological and environmental samples is crucial for advancing biomedical and chemical sciences. Tandem mass spectrometry (MS/MS) is the leading technique for high-throughput elucidation of molecular structures. However, decoding a molecular structure from its mass spectrum is exceptionally challenging, even when performed by human experts.
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