Publications by authors named "T W K Lew"
The pressing issue of food security amid climate change necessitates innovative agricultural practices, including advanced plant genetic engineering techniques. Efficient delivery of biomolecules such as DNA, RNA, and proteins into plant cells is essential for targeted crop improvements, yet traditional methods face significant barriers. This review discusses the multifaceted challenges of biomolecule delivery into plant cells, emphasizing the limitations of conventional methods.
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- Venetoclax is a novel drug that improves outcomes for chronic lymphocytic leukemia (CLL) patients, showing that early treatment response can predict long-term success.
- Researchers used mass cytometry to analyze blood samples from CLL patients and found that venetoclax significantly reduced various CLL cell subpopulations while increasing survival proteins in the remaining cells.
- The study suggests that CLL cells quickly adapt to therapies through survival signals like the B-cell activating factor (BAFF), indicating that combining treatments might lead to more effective and lasting results.
Article Synopsis
- * Overexpressing the Auxin-Regulated Gene involved in Organ Size (ARGOS) in hybrid poplar significantly enlarged organ size and boosted secondary growth and xylem formation.
- * The interaction between PagARGOS and the auxin transporter WALLS ARE THIN1 (WAT1) enhances cambial cell division and xylem differentiation, leading to higher wood yields and lower lignin content, making PagARGOS a promising gene for developing fast-growing, low-lignin trees for better biomass production.
Article Synopsis
- - Chronic lymphocytic leukaemia (CLL) is the most common blood cancer in Australia and New Zealand, with significant advancements in diagnosis and treatment in the past decade.
- - New technologies like next-generation sequencing and flow cytometry help doctors predict outcomes and monitor treatment responses more effectively, while new therapies have improved care for patients, especially those with high-risk genetic issues.
- - Given the unique healthcare landscape in Australasia, experts have created a consensus practice statement to provide standardized guidelines for CLL diagnosis and management, keeping in mind public health concerns like the COVID-19 pandemic.