Publications by authors named "T W Hyde"
Eating disorders (ED) and obsessive-compulsive disorder (OCD) exhibit significant clinical and genetic overlap, yet their shared molecular mechanisms remain unclear. We conducted a transcriptomic investigation of the dorsolateral prefrontal cortex (DLPFC) and caudate from 86 controls, 57 ED, and 27 OCD cases. ED was associated with robust differentially expressed genes (DEGs): 102 DEGs the DLPFC and 222 in the caudate (FDR < 1%) and replicated in an independent cohort.
View Article and Find Full Text PDFArticle Synopsis
- Visium is a transcriptomics assay from 10x Genomics that struggles with overlapping tissue capture areas, needing better tools for combining data from multiple images effectively.
- A new R/Bioconductor package called visiumStitched has been developed to stitch these images together, allowing for more complex analysis while preserving data from overlapping areas.
- While visiumStitched simplifies the handling of multi-capture study designs, it does have some limitations regarding data accuracy when aligning with other reference atlases.
Article Synopsis
- * In children, Lassa fever presents symptoms similar to adults, with high case fatality rates (6-63%), particularly concerning in neonates (66.7%-75%) and significant risks such as bleeding and altered mental status.
- * Developing a safe and effective vaccine is crucial, especially since current trials do not adequately include pregnant/breastfeeding women and young children; targeted strategies for diagnosis, management, and prevention in these high
Article Synopsis
- * Researchers focused on five subdivisions of the primate amygdala in macaques, baboons, and humans, identifying distinct types of excitatory and inhibitory neurons, including specific interneurons.
- * Findings reveal the molecular diversity of amygdalar neuron types, which may enhance current understanding of how these brain circuits affect cognition and mental health, particularly in relation to nonhuman primate models.
Over the last two decades, the diagnosis and treatment of breast cancer patients have considerably improved. However, brain metastases remain a major clinical challenge and a leading cause of mortality. Thus, a better understanding of the pathways involved in the metastatic cascade is essential.
View Article and Find Full Text PDF