Training to Increase Minority Enrollment in Lupus Clinical Trials With Community Engagement: Enhancing Lupus Clinical Trial Recruitment Through Provider and Community Health Worker Engagement.

Objective: This study evaluates the effectiveness of the Training to Increase Minority Enrollment in Lupus Clinical Trials with Community Engagement (TIMELY) program on enhancing referrals of underrepresented patients to lupus clinical trials. TIMELY leverages two existing American College of Rheumatology online educational initiatives: Materials to Increase Minority Involvement in Clinical Trials (MIMICT), a continuing medical education activity for health care providers, and the community health worker (CHW) Lupus Clinical Trials Training (LuCTT). TIMELY introduced a unique roundtable meeting format to build on the existing online educational programs and facilitate discussions between local clinical trial sites and provider and CHW participants.

A Resorcin[4]arene-Based Phosphite-Phosphine Ligand for the Branched-Selective Hydroformylation of Alkyl Alkenes.

Synthesis of a chelating phosphite-phosphine ligand from a tris(quinoxaline) extended resorcin[4]arene and its application in the rhodium-catalyzed hydroformylation of terminal alkyl alkenes are reported. Rhodium complexes are formed within the cavity of the macrocycle and branched-selective hydroformylation of 1-octene with a / ratio of 5.9 has been achieved at 60 °C under 1:1 H/CO (20 bar).

Copper(I) Catalysed Diboron(4) Reduction of Nitrous Oxide.

A process for the catalytic reduction of nitrous oxide using NHC-ligated copper(I) tert-butoxide precatalysts and Bpin as the reductant is reported. These reactions proceed under mild conditions via copper(I)-boryl intermediates which react with NO by facile O-atom insertion into the Cu-B bond and liberate N. Turnover numbers >800 can be achieved at 80 °C under 1 bar NO.

Synthetic and Mechanistic Studies into the Reductive Functionalization of Nitro Compounds Catalyzed by an Iron(salen) Complex.

We report on the use of a simple, bench-stable [Fe(salen)]-μ-oxo precatalyst in the reduction of nitro compounds. The reaction proceeds at room temperature across a range of substrates, including nitro aromatics and aliphatics. By changing the reducing agent from pinacol borane (HBpin) to phenyl silane (HSiPh), we can chemoselectively reduce nitro compounds while retaining carbonyl functionality.