Confronting risks of mirror life.

Broad discussion is needed to chart a path forward.

Mouse innate resistance to infection is driven by early production of IFNγ by NK cells in response to parasite ligands.

Unlabelled: is capable of being transmitted by nearly all warm-blooded animals, and rodents are a major source of parasite dissemination, yet mechanisms driving its broad host range are poorly understood. Although a phylogenetically close relative of , differs from in that it does not infect mice and only infects a small number of ruminant and canine species. We recently showed that and grow similarly in mice during the first 24 h post-infection, but only induces an IFNγ-driven response within hours that controls the infection.

Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis.

Schistosomiasis, a highly prevalent parasitic disease, affects more than 200 million people worldwide. Current diagnostics based on parasite egg detection in stool detect infection only at a late stage, and current antibody-based tests cannot distinguish past from current infection. Here, we developed and used a multiplexed antibody profiling platform to obtain a comprehensive repertoire of antihelminth humoral profiles including isotype, subclass, Fc receptor (FcR) binding, and glycosylation profiles of antigen-specific antibodies.

Going Solo: Techniques for Emergency Fracture Management Without Assistance.

Orthopaedic injuries represent some of the most frequent conditions treated in emergency centers worldwide. Proper reduction techniques and evaluation of radiographic parameters are paramount in treating patients effectively. Orthopaedic providers at large tertiary centers may have several assistants available but are also burdened by notable patient loads and volumes.

Stability and heterogeneity in the antimicrobiota reactivity of human milk-derived immunoglobulin A.

Immunoglobulin A (IgA) is secreted into breast milk and is critical for both protecting against enteric pathogens and shaping the infant intestinal microbiota. The efficacy of breast milk-derived maternal IgA (BrmIgA) is dependent upon its specificity; however, heterogeneity in BrmIgA binding ability to the infant microbiota is not known. Using a flow cytometric array, we analyzed the reactivity of BrmIgA against bacteria common to the infant microbiota and discovered substantial heterogeneity between all donors, independent of preterm or term delivery.