Publications by authors named "T Vittorio"

Article Synopsis
  • * Frailty, which indicates a decline in health, is a key predictor of negative outcomes for older adults, affecting hospitalization rates and recovery, and is relevant in assessing risks for various diseases including cancer, heart disease, and dementia.
  • * The article discusses how frailty indices can help forecast complications, mortality, and long-term health outcomes across different health issues, suggesting that future healthcare approaches should incorporate frailty assessments to improve patient care and reduce adverse effects.
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Heart failure is a complex clinical syndrome that is one of the causes of high mortality worldwide. Additionally, healthcare systems around the world are also being burdened by the aging population and subsequently, increasing estimates of patients with heart failure. As a result, it is crucial to determine novel ways to reduce the healthcare costs, rate of hospitalizations and mortality.

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Background: Cardiovascular diseases (CVD) persist as the leading cause of mortality globally, with atherosclerotic cardiovascular disease (ASCVD), including hypercholesterolaemia, being a significant contributor. Hyperlipidemia management includes various lipid-lowering drugs, including statins, Bempedoic acid, inclisiran, Lomitapide, ANGPTL3 inhibitors, and PCSK9 inhibitors. Statins have traditionally dominated lipid management therapies; however, a subset of patients remains unresponsive or intolerant to this therapy, necessitating novel therapeutic approaches.

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The association between hyperuricemia and cardiovascular diseases has been studied for many years. Research has shown a link between high uric acid levels and increased risk of including coronary artery disease hypertension and other cardiovascular conditions. Urate-lowering therapy, particularly with xanthine oxidase inhibitors like allopurinol, has shown promising results in reducing blood pressure in individuals with hyperuricemia and hypertension.

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Background: Pericardial effusion is associated with amyloidosis, specifically amyloid light chain (AL) and transthyretin (ATTR) subtypes. However, the patients might present with different clinical symptoms.

Objective: To determine the characteristics and associations of patients with pericardial effusion owing to either AL or ATTR amyloidosis.

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