Publications by authors named "T Visakorpi"
Article Synopsis
- Prostate cancer treatment resistance is a major challenge, with genomic studies revealing how cancer cells evade therapies, yet the tumor microenvironment's (TME) role remains unclear.
- A study using advanced techniques on samples from 120 patients offers a detailed transcriptomic profile of the prostate TME throughout the treatment process.
- The research highlights a unique cell type called club-like cells that interact with the immune system, suggesting their involvement in inflammation and resistance to androgen deprivation therapy, indicating they could be potential targets for new treatments.
While hundreds of cancer-associated long noncoding RNAs (lncRNAs) have been discovered, their functional role in cancer cells is still largely a mystery. An increasing number of lncRNAs are recognized to function in the cytoplasm, e.g.
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- Cancer cells experience significant changes in gene expression and epigenetics, including the abnormal activation of certain tissue-specific genes.
- The RNA helicase DDX4 forms structures similar to germ granules in tumors but not in cultured cancer cells, containing proteins linked to RNA and splicing.
- The absence of DDX4 in cancer cells alters gene expression, reduces cancer growth and invasiveness, and is associated with poorer patient outcomes in certain cancers like head and neck squamous cell carcinoma and advanced prostate cancer.
Article Synopsis
- - The study examines the genomic heterogeneity of prostate cancer and its impact on treatment resistance, suggesting that incorporating evolutionary principles into clinical trials could provide valuable insights for therapy strategies.
- - Researchers analyzed whole genome data and 3D anatomical structures from two patients with high-risk prostate cancer, using advanced tools to map tumor origins, genetic mutations, and metastasis patterns.
- - Results indicate that specific mutations and evolutionary patterns significantly influence cancer progression and metastasis, highlighting the potential for evolutionary analysis to inform therapy choices in prostate cancer patients.
Prostate cancer (PCa) is the second-most common cause of male cancer-related death in western industrialized countries, and the emergence of metastases is a key challenge in the treatment of PCa. Accumulating studies have shown that long noncoding RNAs (lncRNAs) play an important role in the regulation of diverse cellular and molecular processes during the development and progression of cancer. Here, we utilized a unique cohort of castration-resistant prostate cancer metastases (mCRPC) and corresponding localized tumors and RNA sequencing (RNA-seq).
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