Publications by authors named "T Virtanen"
The tumor immune microenvironment (TiME) of human central nervous system (CNS) tumors remains to be comprehensively deciphered. Here, we employed flow cytometry and RNA sequencing analysis for a deep data-driven dissection of a diverse TiME and to uncover noncanonical immune cell types in human CNS tumors by using seven tumors from five patients. Myeloid subsets comprised classical microglia, monocyte-derived macrophages, neutrophils, and two noncanonical myeloid subsets: CD3 myeloids and CD19 myeloids.
View Article and Find Full Text PDFArticle Synopsis
- Northern herbivores significantly impact tundra ecosystems, but the effects of herbivore diversity on these ecosystems have been largely overlooked, especially with ongoing climate and land-use changes.
- This systematic review analyzed numerous studies (201 articles and over 3700 individual comparisons) to understand how different levels of herbivore diversity (measured by functional group richness) influence ecosystem processes and functions in the tundra.
- The findings highlight a concentrated body of research from specific locations, emphasizing the need for more comprehensive studies across diverse Arctic regions to grasp the full effects of herbivore diversity on ecosystem functionality.
Battles in the cyber domain often lack visibility compared to the physical domain, which can lead to insufficient appreciation of its actors' achievements by the general public and society. Nonetheless, it has become a crucial area of modern warfare in which cyber professionals defend the nation's critical infrastructure, support other military operations and achieve military objectives that could not be attained in other domains. Although cyber combatants might not have as high a risk of injury or death as those on the front lines, they still can face traumatic events and suffer from the same types of issues after the war as any other veteran.
View Article and Find Full Text PDFArticle Synopsis
- * In a study involving 264 plasma samples from 63 EOC patients, ctDNA was found in 93% of samples at diagnosis and 100% at disease progression, indicating its effectiveness for monitoring.
- * Positive ctDNA results after treatment correlated with faster disease progression and lower survival rates, and in some cases, ctDNA detected recurrence earlier than traditional methods by an average of 5.9 months.