Bioavailability of Cariban Capsules: A Modified-Release Fixed-Dose Combination of Doxylamine and Pyridoxine to Relieve Nausea and Vomiting During Pregnancy.

Background: Nausea and vomiting is a very prevalent condition during pregnancy. Combination of doxylamine and pyridoxine is placed as first-line pharmacological option for its treatment in most clinical guidelines. Among different release forms available, Cariban is a fixed-dose combination of doxylamine/pyridoxine 10/10 mg, formulated as modified-release capsules.

Disease burden associated with alpha-1 antitrypsin deficiency: systematic and structured literature reviews.

Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder characterised by reduced levels of circulating alpha-1 antitrypsin and an increased risk of lung and liver disease. Recent reviews of AATD have focused on diagnosis, epidemiology and clinical management; comprehensive reviews examining disease burden are lacking. Therefore, we conducted literature reviews to investigate the AATD disease burden for patients, caregivers and healthcare systems.

[Fluorine in parenteral nutrition solutions].

The daily contribution of F in patients subjected to TPN has been determined, based on the F content of 61 commercial solutions used to prepare the different TPN. The determinations have been done by means of a potentiometric method with and F selective electrode and a double union reference electrode. Only those commercial solutions contained in glass ampules showed traces of F, while none was detected in samples contained in plastic or other type of glass containers.

[Nickel content of parenteral nutrition solutions].

Determination of the nickel content in 49 commercial solutions used in parenteral nutrition, by means of atomic absorption spectroscopy in a graphite kiln. Important differences were found between the different components (less than 5 to 23.000 ppb).

[Thiamine stability in parenteral nutrition].

In the present work we have studied the stability of thiamine by HPLC in parenteral nutritions provided with or without lipids. As source of nitrogen we have used Freamine 8.5%.