Remodeling of the cardiac striatin interactome and its dynamics in the diabetic heart.

Diabetic cardiomyopathy (DbCM) is a silent and complex condition involving numerous signaling pathways that impair cardiomyocyte metabolism and cardiac performance. Striatin (STRN) is a multifaceted protein that binds metabolic proteins, yet its role in diabetic heart remains unexplored. Here we characterized the cardiac STRN interactome by performing immunoprecipitation on left ventricle (LV) proteins from control and diabetic hearts (rats treated with streptozotocin for 24 weeks) to dissect its derivative protein complex.

Correction: Circulating microRNAs as potential biomarkers of early vascular damage in vitamin D deficiency, obese, and diabetic patients.

[This corrects the article DOI: 10.1371/journal.pone.

Azithromycin targets the CD27 pathway to modulate CD27hi T-lymphocyte expansion and type-1 effector phenotype.

Macrolide antibiotic azithromycin is widely used in clinical practice to treat respiratory tract infections and inflammatory diseases. However, its mechanism of action is not fully understood. Given the involvement of the CD27 pathway in the pathophysiology of various T-lymphocyte-mediated inflammatory, autoimmune, and lymphoproliferative diseases, we examined the impact of AZM on CD27 regulation and potential consequences on CD4+ and CD8+ T-cell phenotypes.

CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases.

Coordinated activation and inhibition of F-actin supports the movements of morphogenesis. Understanding the proteins that regulate F-actin is important, since these proteins are mis-regulated in diseases like cancer. Our studies of C.