Publications by authors named "T Van den Kerkhof"
Article Synopsis
- Previous animal studies indicated concerns about salbutamol's effects on lung injury when exposed to ozone air pollution.
- A double-blind, randomized, placebo-controlled study involved 18 participants with exercise-induced bronchospasm (EIB) testing the impacts of salbutamol in both ozone and room air during exercise.
- Results showed that salbutamol significantly improved lung function without increasing airway inflammation, suggesting it is safe for EIB patients to use the medication during high ozone conditions.
Background: The HVTN 705 Imbokodo trial of 2636 people without HIV and assigned female sex at birth, conducted in southern Africa, evaluated a heterologous HIV-1 vaccine regimen: mosaic adenovirus 26-based vaccine (Ad26.Mos4.HIV) at Months 0, 3, 6, 12 and alum-adjuvanted clade C gp140 at Months 6, 12.
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- * The authors created a method called MASCALE that uses mass spectrometry to accurately quantify antibody levels by calibrating ELISA reference sera.
- * MASCALE allows for improved comparison of immune responses across different labs and studies, helping to better evaluate vaccine efficacy and immune responses in clinical trials.
Background And Objective: Exercise in hot environments impairs endurance performance. Cooling interventions can attenuate the impact of heat stress on performance, but the influence of an exercise protocol on the magnitude of performance benefit remains unknown. This meta-analytical review compared the effects of pre- and per-cooling interventions on performance during self-paced and constant workload exercise in the heat.
View Article and Find Full Text PDFBroadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subtypes and are able to prevent HIV-1 infection in animal models. However, bNAbs are extremely difficult to induce by vaccination. Defining the developmental pathways towards neutralization breadth can assist in the design of strategies to elicit protective bNAb responses by vaccination.
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