Publications by authors named "T Van Metre"
The present work focuses on the synthesis of novel heterocycles 2-(aryloxy)-3-(4,5-diaryl-1H-imidazol-2-yl)quinolines (6k-v) by an effective condensation reaction. These molecules exhibited fluorescent properties and hence for the proper understanding of their optical behavior and quantum yields, solvatochromic studies have been carried out. Further, frontier molecular orbitals, molecular electrostatic potential (MEP), and geometrical structure optimization have been investigated using the BLYP/6-311G ++ (d, p) method.
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- The study presents a method to create a chitosan-silver nanocomposite (CS-Ag NC) using kiwi fruit juice, which serves as a natural reducing agent.
- Various characterization techniques confirmed the structure and properties of the CS-Ag NC, which was then employed as a catalyst to convert 4-nitrophenol into 4-aminophenol.
- The nanocomposite demonstrated significant cytotoxic effects against various cancer cell lines and showed promising wound healing properties, with a high percentage of wound closure comparable to a standard drug.
Article Synopsis
- Thiazolidinedione (TZD) drugs improve insulin sensitivity and manage blood sugar levels in type 2 diabetes patients.
- A new series of compounds called coumarin-4-yl-1,2,3-triazol-4-yl-methyl-thiazolidine-2,4-diones (TZD1-TZD18) were created using "Click Chemistry" and tested for their effectiveness in glucose uptake and toxicity against human kidney cells.
- The study found that the compounds TZD4, TZD10, TZD14, and TZD16 were particularly effective in lowering blood glucose levels, outperforming the standard medication, Pioglitazone.
Pain and dermal reaction caused by injected glycerin in immunotherapy solutions.
J Allergy Clin Immunol
May 1996
Background: Fifty percent glycerin preserves immunotherapy solution potency for at least 3 years but must be diluted before injection to reduce glycerin-induced pain and inflammation. We studied pain, erythema, induration, and bruises caused by glycerin (0% to 30%).
Methods: In 15 healthy subjects we compared, in double-blind fashion, pain scores, injection site erythema, induration, and bruising caused by subcutaneous injections in randomized order of 0.