Publications by authors named "T V Yakovleva"
Article Synopsis
- - The study focuses on correcting mutations in the CASR gene, which is crucial for regulating calcium levels in the body, specifically targeting mutations linked to a severe condition called neonatal primary hyperparathyroidism.
- - Researchers generated a CRISPR/Cas9 edited human induced pluripotent stem cell (hiPSC) line that successfully restored one of the mutations while preserving another, showing normal characteristics such as cell structure and growth potential.
- - The newly created hiPSC line will be used as a valuable resource for understanding calcium regulation disorders and exploring personalized medicine approaches to treat these conditions in the future.
The transcription of organellar genes is performed by three nuclear-encoded RNA polymerases: RPOTm, RPOTmp, and RPOTp. The RPOTmp protein possesses ambiguous transit peptides, allowing participation in gene expression control in both mitochondria and chloroplasts, although its function in plastids is still under discussion. Here, we show that the overexpression of RPOTmp in , targeted either to mitochondria or chloroplasts, disturbs the dormant seed state, and it causes the following effects: earlier germination, decreased ABA sensitivity, faster seedling growth, and earlier flowering.
View Article and Find Full Text PDFIn this study, the microstructural behavior of the advanced Ti-5.7Al-3.8Mo-1.
View Article and Find Full Text PDFDapagliflozin-induced improvement of glycemic control in patients with inadequately controlled type 1 diabetes (T1D) is complicated by the delicate balance between blood glucose and exogenous insulin. In this work, we developed a semi-mechanistic population exposure-response model using pooled patient-level data to characterize the joint effect of dapagliflozin and insulin on average daily glucose concentrations and glycated hemoglobin (HbA1c) levels in patients with T1D. A non-linear mixed-effects model was developed in Monolix (Lixoft, France) and R software (R Project, www.
View Article and Find Full Text PDFThe paper addresses a crucial challenge in medical radiology and introduces a novel general approach, which utilises applied mathematics and information technology techniques, for aberration correction in ultrasound diagnostics. Ultrasound imaging of inhomogeneous media inherently suffers from variations in ultrasonic speed between tissue. The characteristics of aberrations are unique to each patient due to tissue morphology.
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