[Gonadotropin-dependent precocious puberty: genetic and clinical characteristics].

Background: In 90% cases of girls and 25-60% cases of boys the cause of gonadotropin-dependent precocious puberty (PP) is unclear. Up to 25-27.5% of gonadotropin-dependent PP cases are monogenic and suggest autosomal-dominant inheritance with incomplete sex-dependent penetrance.

Identification of the novel HLA-B*07:458 allele, detected in two unrelated bone marrow donors.

HLA-B*07:458 has one non-synonymous nucleotide compared with HLA-B*07:02:01 in codon-21.