Case Report: Loss-of-Function Genetic Variant Associated With Ventricular Fibrillation.

Genetic variants in the gene, encoding the SUR2 auxiliary subunit from K channels, were previously linked with various inherited diseases. This wide range of congenital disorders includes multisystem and cardiovascular pathologies. The gain-of-function mutations result in Cantu syndrome, acromegaloid facial appearance, hypertrichosis, and acromegaloid facial features.

Combination of lead-field theory with cardiac vector direction: ECG imaging of septal ventricular activation.

Background: Despite the tremendous progress recently reported in ECG imaging (ECGI), some fundamental challenges are still hindering this non-invasive technology from meeting rising clinical expectations. In the present work, we address one of the major ECGI shortcomings in reconstruction of ventricular activation - the limited accuracy of endocardial and particularly septal mapping.

Methods: Ten CRT patients (five female, median (min-max) age - 61 (27-78) years) with previously implanted CRT devices underwent ECGI with isolated right ventricular (RV) pacing.

[Automatic detection of ventricular and supraventricular wide QRS arrhythmias using complex of morphological criteria and algorithms].

Aim: The aim of study is a detection of ventricular and supraventricular wide QRS arrhythmias using complex of morphological criteria and algorithms by method of automatic analysis.

Materials And Methods: For 100 patients (m/f - 61/39, Me (min; max) - 44.5 (10; 85) years) of researched group the analysis of 14306 single wide ectopic complexes (QRS 120-230 ms) has been done.

ECG Adapted Fastest Route Algorithm to Localize the Ectopic Excitation Origin in CRT Patients.

Although model-based solution strategies for the ECGI were reported to deliver promising clinical results, they strongly rely on some a priori assumptions, which do not hold true for many pathological cases. The fastest route algorithm (FRA) is a well-established method for noninvasive imaging of ectopic activities. It generates test activation sequences on the heart and compares the corresponding test body surface potential maps (BSPMs) to the measured ones.

[Algorithm for the management of patients with stable coronary artery disease and high-grade ventricular arrhythmias].

The paper gives an original algorithm for the management of patients with stable coronary artery disease, preserved/moderately reduced left ventricular systolic function, and high-grade ventricular arrhythmias from the first registration of the latter to the choice of treatment policy. Great attention is paid to the assessment of a private clinical case, by determining the nature of arrhythmias, and to the involvement of autonomic regulation in the genesis of ventricular arrhythmias. The importance of topical diagnosis of ventricular arrhythmias and identification of psychological disorders is emphasized.