[Genetically determined organ-specific changes of some tissue morphometric characteristics under the various exogenous influences].

Organ-specific alterations of ultrastructure and morphofunctional condition in different organism's tissues, which could evidence of the genetic factors inclusion under the development of different hypoxic condition in organism, were investigated. The dates obtained indicated the marked organ-specific "structure" reaction of tissues, cells and organelles under various exogenous influences. Such reactions confirm the presence of different genes expression which account for ultrastructure alterations; its activity is determined by a type, intensity, duration of influence as well as organ belonging.

[Correlation of tissue respiration and some mitochondria stereometric characteristics of the lung tissue in different modifications of hypoxic hypoxia].

In experiments on the adult white laboratory rats the correlation of tissue respiration and some morpho- and stereometric characteristics of mitochondria in lung tissue under breathing by air and gas mixture with 7% O2 in N2 was investigated. The following agents were used as modulators: indomethacin, a blockator of cyclooxygenase way of arachidonic acid metabolism; quercetin and linoleil of hydroxamic acid, blockators of lipooxygenase way ofarachidonic acid metabolism; taurine, an antihypoxant and energy source under hypoxic conditions; lipin-antihypoxant with significant membrane protective effect. It was shown, that the respiration intensity of tissue homogenate, not only of its mitochondrial fraction, closely connected with structural organization of mitochondria.