Molecular Subgroups of HRD Positive Ovarian Cancer and Their Prognostic Significance.

Homologous recombination repair deficiency (HRD) is involved in the development of high-grade serous ovarian carcinoma (HGSOC) and its elevated sensitivity to platinum-based chemotherapy. To investigate the heterogeneity of the HRD-positive HGSOC we evaluated the HRD status, including BRCA mutations, genomic scar score, and methylation status of genes in 352 HGSOC specimens. We then divided the HRD-positive cohort into three molecular subgroups, the BRCA mutation cohort (BRCA+), BRCA1 methylation cohort (Meth+), and the rest of the HRD+ cohort (HRD+BRCA-Meth-), and evaluated their first-line chemotherapy response, benefit from olaparib, and progression-free survival (PFS).

Optimization and scaling up of extracellular polysaccharide production by submerged culture of Ganoderma lucidum on starch-containing medium using response surface methodology and laboratory bioreactors of various designs.

Basidiomycetes, known for their production of bioactive compounds, traditionally use simple sugars for fermentation. However, their ability to degrade complex plant polysaccharides through enzyme secretion presents potential for the use of renewable raw materials. This study focused on the optimization of exopolysaccharide (EPS) production and efficient substrate consumption by Ganoderma lucidum using response surface methodology (RSM).

The Interaction between Congruency and Numerical Ratio Effects in the Nonsymbolic Comparison Test.

The nonsymbolic comparison task is used to investigate the precision of the Approximate Number Sense, the ability to process discrete numerosity without counting and symbols. There is an ongoing debate regarding the extent to which the ANS is influenced by the processing of non-numerical visual cues. To address this question, we assessed the congruency effect in a nonsymbolic comparison task, examining its variability across different stimulus presentation formats and numerical proportions.

Processing Speed throughout Primary School Education: Evidence from a Cross-Country Longitudinal Study.

This cross-country four-year longitudinal study investigated the development of processing speed throughout primary school education. The analyses were conducted on data accumulated from 441 pupils in grades from 1 to 4 (aged 6.42 to 11.

HRD Testing of Ovarian Cancer in Routine Practice: What Are We Dealing With?

Assessment of homologous recombination deficiency (HRD) status is now essential for ovarian cancer patient management. The aim of our study was to analyze the influence of ethnic variations, tumor purity, and neoadjuvant chemotherapy (CT) on the determination of HRD scores as well as to evaluate feasibility of HRD testing with the Amoy HRD Focus Assay in routine clinical practice. The HRD status, including the status and genomic scar score (GSS), was analyzed in 452 ovarian cancer specimens.