Publications by authors named "T V Strong"
Inpatient hospitalisations for patients with Prader-Willi syndrome: a 2019-2021 National Inpatient Sample analysis.
J Intellect Disabil Res
January 2025
Background: Prader-Willi syndrome (PWS) is a genetic disorder characterised by hyperphagia, intellectual disability and increased propensity to a range of medical disorders. To better characterise the clinical presentation of PWS across the lifespan, this study reports on the demographics and clinical diagnosis of individuals with PWS hospitalised in the United States.
Methods: The National Inpatient Sample, an all-payor administrative claims database of hospitalisations in the United States, was queried for patients with a coded diagnosis of PWS from October 2019 through December 2021.
Article Synopsis
- - Prader-Willi syndrome (PWS) is a genetic disorder due to missing genes on chromosome 15, leading to excessive eating, behavior issues, and varying intellectual disability, making early diagnosis and communication tricky for families.
- - A study investigated how parents of children with PWS share the diagnosis with their kids, using surveys and interviews from 51 parents, revealing that 90% had disclosed some information based on their knowledge and their child's age or presence of siblings.
- - The analysis identified 15 themes on parents' motivations and methods for disclosing the diagnosis, offering insights for others facing similar situations with rare conditions.
Background: Prader-Willi syndrome (PWS) is a genetic disorder associated with baseline respiratory impairment caused by multiple contributing etiologies. While this may be expected to increase the risk of severe COVID-19 infections in PWS patients, survey studies have suggested paradoxically low disease severity. To better characterize the course of COVID-19 infection in patients with PWS, this study analyzes the outcomes of hospitalizations for COVID-19 among patients with and without PWS.
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- Prader-Willi syndrome (PWS) is a rare genetic disorder linked to the absence of certain genes on chromosome 15, leading to symptoms like low muscle tone, cognitive issues, and a constant urge to eat, which can cause severe obesity if not managed.
- The study assessed the long-term effectiveness of Diazoxide choline extended-release (DCCR) tablets on managing hyperphagia and other behavioral issues in PWS patients through comparisons between a treatment cohort and a natural history study cohort.
- Results showed that those treated with DCCR exhibited significant reductions in hyperphagia scores and improvements in behavioral assessments over 26 and 52 weeks, with findings remaining consistent even under worst-case data scenarios. *
Subacute spinal cord injury (SCI) displays a complex pathophysiology associated with pro-inflammation and ensuing tissue damage. Microglia, the resident innate immune cells of the CNS, in concert with infiltrating macrophages, are the primary contributors to SCI-induced inflammation. However, subpopulations of activated microglia can also possess immunomodulatory activities that are essential for tissue remodeling and repair, including the production of anti-inflammatory cytokines and growth factors that are vital for SCI recovery.
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