[Study of the glycosaminoglycan-glycosaminoglycan hydrolase system for evaluation of the healing dynamics in stomach and duodenal ulcer].

When studying the state of metabolism of the main substance of the connective tissue (glycosaminoglycan (GAG) and one of gag-hydrolases) in case of stomach and duodenal ulcers in patients under in-patient clinic conditions, it was shown that the amount of GAG in the urine approximately doubles in both groups in the state of exacerbation, and the given index reduces to the norm in the state of remission with a insignificant fluctuation of the b-glucuronidase level in the blood serum.

[The effect of D-penicillamine on the metabolism of the basic substance of the connective tissue and the indices of the liver parenchyma in experimental cirrhosis in rats].

While examining the effects of D-penicillamine [correction of D-penicillin] on the formation of hepatic toxic damage in mature male Wistar rats from the stage of developing cirrhosis to that of the developed one, the author revealed a high antifibrotic activity of the drug which significantly normalized the metabolism of the major agent of the hepatic connective tissue; there was a slight improvement of parenchymal metabolism when the agent was taken for 2 months. There were apparently healthy animals in the experimental group following 4-month course of the therapy. Control rats developed hepatic damage, as evidenced by electron microscopic studies.

[Metabolism of the basic component of connective tissue at various stages of developing experimental liver cirrhosis].

A system of GAG-hydrolase was studied in liver tissue and blood plasma during development of CCl4-produced cirrhosis of liver tissue in series of experiments involving 400 adult rat males. Dissimilar pathways of the matrix formation, related to dynamics of the GAG-hydrolases activity, were detected within various steps of the chronic CCL4-produced liver tissue impairments in these rats. Alterations in the enzymatic activity were stable and regular in each series of the experiment and correlated with dynamics of the adaptation-compensatory responses.

[Effects of D-penicillamine on the ultrastructure of hepatocytes and state of the base substance in the liver of rats with experimental cirrhosis].

The authors examined the action of D-penicillamine on the ultrastructure of hepatocytes and the condition of the base substance in the rat's liver, with experimental CCl4-cirrhosis. (D-penicillamine was given to these rats during 4 and 6 months). It was discovered that the using of D-penicillamine on the early stages of experiment (until 4 months) reduced the process of the development of the liver cirrhosis.