Publications by authors named "T V Shiva Shankar"
Background: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial.
View Article and Find Full Text PDFExtrapleural hematoma is a rare consequence of thoracic trauma, which is the result of bleeding between the parietal pleura and the endothoracic fascia and is usually diagnosed within the initial 24-48 hours of the injury. Delayed presentations are rarely seen. An elderly male, who was not on any antiplatelet or anticoagulant medications, presented to the emergency department six days after sustaining a trivial blunt chest trauma with a large right extrapleural hematoma.
View Article and Find Full Text PDFLactate is the highest turnover circulating metabolite in mammals. While traditionally viewed as a waste product, lactate is an important energy source for many organs, but first must be oxidized to pyruvate for entry into the tricarboxylic acid cycle (TCA cycle). This reaction is thought to occur in the cytosol, with pyruvate subsequently transported into mitochondria via the mitochondrial pyruvate carrier (MPC).
View Article and Find Full Text PDFArticle Synopsis
- Recurrent respiratory papillomatosis is a benign but aggressive condition caused mainly by HPV types 6 and 11, leading to the formation of warts in the respiratory tract, particularly the larynx, necessitating multiple surgeries for management.
- A study conducted on 13 patients aged 3 to 30 evaluated the effects of intralesional bevacizumab as an adjuvant therapy, which involved three injections over 12 weeks.
- The results indicated that this treatment significantly extended the time between surgeries and reduced the total number of procedures needed each year, with no reported adverse effects, showing improvements in patient health as measured by the Derkay score.