PSYCHOLOGICAL STATE AND TYPOLOGICAL PERSONALITY FEATURES OF CHILDREN RESIDENTS OF RADIOACTIVELY CONTAMINATED TERRITORIES IN THE REMOTE PERIOD OF CHORNOBYL СATASTROPHE.

Objective: To evaluate the psycho-emotional state of children-residents of radioactively contaminated territoriesand to characterize the typological features of their personality in the remote period of the Chornobyl catastrophe.

Materials And Methods: Psycho-emotional status and typological personality traits were determined in 96 childrenaged 12 to 17 years, who resided in radioactively contaminated territories with a soil contamination density of 137Csabove 185 kBq/m-2, and were admitted for examination and treatment in the pediatric departments of the NRCRMclinic. Psycho-emotional state of children was determined using the test «non-existent animal», which was assessedin points on symptom complexes: anxiety, aggression and neuro-mental exhaustion.

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface.

Objective- After activation at the site of vascular injury, platelets differentiate into 2 subpopulations, exhibiting either proaggregatory or procoagulant phenotype. Although the functional role of proaggregatory platelets is well established, the physiological significance of procoagulant platelets, the dynamics of their formation, and spatial distribution in thrombus remain elusive. Approach and Results- Using transmission electron microscopy and fluorescence microscopy of arterial thrombi formed in vivo after ferric chloride-induced injury of carotid artery or mechanical injury of abdominal aorta in mice, we demonstrate that procoagulant platelets are located at the periphery of the formed thrombi.

Systems biology insights into the meaning of the platelet's dual-receptor thrombin signaling.

Unlabelled: Essentials Roles of the two thrombin receptors in platelet signaling are poorly understood. Computational systems biology modeling was used together with continuous flow cytometry. Dual-receptor system has wide-range sensitivity to thrombin and optimal response dynamics.