[Bacterial overgrowth syndrome in the small intestine: pathogenesis, clinical significance and therapy tactics].

The redundant bacterial growth syndrome in the small intestine is associated with the increased total semination of over 10(5) CFU/ml presented by enterobacteria, bacteroids, clostridia, fusobacteria, etc. It is developed at the dysfunction of the gastrointestinal tract, insufficient bacteria inhibition at the time when they come from the large intestine (atony, stasis, bypasses) and is accompanied by the enhanced intestinal barrier permeability along with chronic diarrhea and intoxication. Intestinal absorption disorders cause B12-deficiency anemia, hypovitaminosis and protein deficiency.

[Microecological aspects of small intestinal bacterial overgrowth syndrome].

Small intestinal bacterial overgrowth syndrome (SIBOS) means chronic recurrent diarrhea with malabsorption, intoxication and increased risk of endogenous infection. This syndrome are accompanied by increase of overall bacterial burden in biotope >10(5) CFU/ml in adults and >10(4) CFU/ml in children, emergence of different species of enterobacteria, bacteroides, clostridia and fusobacteria et al. in small intestine.

Probiotics and mechanisms of their curative action.

Information about probiotics used for the correction of resident normal colon microflora and mechanism of their positive therapeutic actions are presented. Probiotics are drugs containing live microbes or substances of microbial origin that, when introduced by natural methods, are expected to confer beneficial physiologic, biochemical and immune effects to the host through the stabilization and optimization of functions of normal microflora. Probiotics containing the Bifidobacterium, Lactobacillus, Escherichia, Enterococcus, Asporogenic aerobe Bacillus and Saccharomyces boulardii microorganisms are characterized.

[Correction of intestinal dysbacteriosis in elderly patients with the use of bifidobacterin introduced by different routes].

The results of the correction of disturbances in intestinal microflora in elderly patients with the use of bifidumbacterin in the form of powder or suppositories are presented. The effectiveness of the rectal administration of bifidumbacterin (by microinjections through an enema or in suppositories) is shown in comparison with the oral administration of the preparation. The administration of bifidumbacterin in suppositories for 15 days resulted in decreased content of hemolytic Escherichia below the threshold of determination in all examined patients.

[The microecological disorders in clinical pathology and their correction by bifidum-containing probiotics].

On the basis of independent research and published data surveyed in the paper is the prevalence and nature of disorders of the intestinal microflora observed in adults and children with different pathologies, i.e. chronic diseases of the gastrointestinal tract, acute intestinal infections, acute respiratory viral infections, pneumonias, as well as certain nephrological, gynecological, and surgical diseases etc.