[Nicotine effect on cell immunity in rats with adjuvant induced monoarthritis].

The effect of subchronic nicotine consumption on cell immunity in rats with adjuvant-induced monoarthritis and in intact animals was investigated. In intact animals, nicotine intake was associated with increase of absolute T-cell number and T-cell proliferative response to mitrogen stimulation in vitro, the latter being not due to the altered lymphocyte sensitivity to glucocorticoids. Nicotine intake by rats with arthritis resulted in significant expansion of T-helper and cytotoxic cells and decrease of natural killers in blood.

[Markers of inflammation--monocyte chemoattractant protein-1 (MCP-1) and C-reactive protein--in blood of patients with unstable angina pectoris and stable effort angina].

Aim: To estimate concentrations of C-reactive protein (CRP) and MCP-1 in blood plasma of patients with unstable angina (UA) and stable effort angina (SEA).

Material And Methods: Multiprojection coronaroangiography was performed in 12 patients with UA and 11 patients with SEA. Hemodynamically significant stenosis (50% and more) at least in one major coronary artery was confirmed in all the patients.

[Markers of inflammation, autoantibodies to neurospecific antigens and outcome in patients with acute ischemic stroke].

To identify biochemical markers for carotid stroke outcome, blood serum levels of inflammation markers (C-reactive protein, orosomucoid, soluble p-selectin) and autoantibodies (AAB) to neurospecific antigens (glial fibrillary acidic protein, neuron specific enolase, S-100 protein) were studied in 27 patients (mean age 64 +/- 6 years) with acute ischemic stroke in inner carotid artery system on day 1-2 and 21 of the disease onset. To day 21, patients with good rehabilitation of neurological functions (group 1) demonstrated a decrease of C-reactive protein and soluble p-selectin concentrations, and unfavorable disease course was associated with a significant (p<0.05) increase of concentrations of these indices.

[Potential influence of nicotine on inflammation and induction of autoantibodies in rats with adjuvant arthritis].

The influence of chronic administration of nicotine diluted in the drinking water on the parameters of systemic inflammation and autoimmune processes in rats (August line) with adjuvant-induced arthritis, were studied. The experiments have shown that nicotine acts as an antiphlogistic means (the amount of C-reactive protein rises in the blood) and activates autoimmune processes: induction of rheumatic factor, of autoantibodies to serotonin, and glial fibrillar acid protein. It was supposed that nicotine has a potential impact on immunocompetent cells.

[Possibility of selective binding of HIV-1 infected cells by immunosorbents].

A study was made of a possibility of specific sorption of HIV-1 infected cells with gamma-fraction of AIDS patients' serum containing high titer-specific antibodies, immobilized on the silica matrix (C-3). The laboratory tests were made with the use of the monocyte culture [symbol: see text] chronically infected with HIV-1. In addition to a decrease of the cell count after sorption, there was a decline of the activity of antigen material in the samples (to 43% of the initial).